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Ontario Equestrian Contributes Toward Gains for Gut Research July 2018
Story: Jackie Bellamy-Zions
Simulated Gut Study- “Rogo-gut” “The funding from Ontario Equestrian is very timely and crucial for the acquisition of specialized equipment, material and supplies needed to achieve our goals,” says Arroyo. “I am deeply grateful for their support of this research program and the investment to this devastating equine illness, colitis.”The microbial communities of the gut play a crucial role in the health of the horse, and we know now that there are major differences between the gut microbiota of healthy horses and those with colitis. In more recent years, mimicking the growth environment and nutritional conditions of the natural habitat of bacteria has revolutionized traditional bacterial culture. The bacteria populations (particularly the anaerobes) within the large colon can now be better characterized in health and disease by combining culture enriched-based methods and molecular profiling of intestinal contents of horses with or without colitis. With the help of Dr. Emma Allen-Vercoe (designer of the human Robogut), Arroyo is setting up a simulated gut to help understand what a healthy horse microbiome looks like. Just as scientists now believe that many cases of colitis in humans are due to imbalances in the microbiome, and not pathogens as was previously thought; these findings are guiding the research into the microbiome and colitis in horses. On Poop Patrol Weese and his team are looking to find out how much the ‘normal’ horses microbiota changes, over the course of a year, with a study that will frequently collect and examine fecal samples from 15 - 20 horses.
By analyzing samples from healthy horses over the course of a year they will learn if the microbiota are impacted by seasonal changes, gain insight on different diets and how they affect the microbial population and study composition versus function of microbiota. Weese proposes from horse to horse, it may be possible to have completely different bugs performing the exact same functions. “When it comes to diagnosing disease, at the moment there is not enough knowledge of the equine intestinal microbiota to determine the difference between incidental or cause and effect links,” says Weese. In humans there are links between endocrine disease, obesity and gut function. There is also great interest in establishing links between the gut microbiota and metabolic diseases in horses, with finding just starting to emerge. We typically think of the gut in terms of colic, laminitis and colitis but there is likely many more things equine gut microbiota can influence or be impacted by such as: insulin resistance or gastrointestinal disease following antibiotic administration. The future is exciting with the possibilities of restoration of normal microbiota as a reasonable clinical goal for prevention or treatment. But first things first for Weese means getting the scoop on poop for the baselines of ‘normal’ microbiota. |